kalmanis sindromi

kalmanis sindromi warmoadgens genetikur paTlogias/darRvevas, romlis drosac sqesobrivi momwifeba darRveuli da dausrulebelia. am dros gamoxatulia sasqeso hormonebis testosteronis (kacebSi) estrogenebis da progesteroni (qalebSi) deficiti – hipogonadizmi. am mdgomareobas sxvagvarad hipogonadotropul hipogonadizmsac uwodeben.

kalmanis sindromi asocirebulia ynosvis SegrZnebis darRvevasTan, umetead mis saerTod dakargvasTan – anosmia. swored amitom gamoiyofa kalmanis sindromi hipogonadotropuli hipogonadizmisgan, sxva mxriv sxvaoba ar aris.

mdgomareobas Tan axlavs folikulo mastimulirebeli hormonis da maluTeinizirebeli hormonis nakleboba, romelis Sedegia sasqeso hormonebis nakleboba. am dros darRveulia sqesobrivi momwifeba, iwyeba gvian da ar sruldeba srulad.

kalmanis sindromi sakmaod iSviaTi mdgomareobaa, viTardeba 1 adamianSi 10 000 dan. 5 jer ufro xSiria kacebSi, kvidre qalebSi.

kalmanis sindromiT yvelaze cnobili adamiani iyo jaz vokalisti jimi skoti, romelic aseve „patara jimis“ saxeliT aris cnobili.

kalmanis sindromis niSnebi da simptomebi:
sqesobrivi momwifebis gvian dawyeba da srulad ar damTavreba, rogorc qalebSi, aseve mamakacebSi.
saTesleebis ganuviTarebloba < 3 ml.
pirveladi amenorea.
sustad gamoxatuli meoradi sasqeso niSnebi, rogorc qalebSi, aseve kacebSi (ar aris kacisTvis damaxasiaTebeli Tmianoba, sxeulis formebi da a.S.).
unayofoba
mglis xaxa
kriptorqidizmi
mikropenisi
smenis problemebi
kbilebis defeqtebi
saSualod normaluri simaRlisani arian.

es niSnebi ari aris saerTo damaxasiaTebeli yvela SemTxvevisTvis.

kalmanis sindromis dros bavSvebSi sqesobriv momwifebamde SeiZleba aranairi simptomebi ar iyos gamokveTili.

ZiriTadi sadiagnostiko kriteriumebia simptomebi da niSnebi + gonadotropinebis, Sedegad sasqeso hormonebis nakleboba.

mkurnalobas warmoadgens hormonuli CanacvlebiTi Terapia, romlelic mniSvnelovania fiziologiuri sasqeso hormonuli donis aRdgenisTvis.