Samedicino seqsologia
dofamini
da jeims evensis mier londonSi. dofaminis funqciebi ki 1958 wels ervid karlsonma gansazRvra risTvisac 2000 welSi nobelis premia daimsaxura fiziologia/medicina – Si. man gansazRvra, rom dofamini ar iyo mxolod noradrenalinis da adrenalinis prekursori, aramed mas gaaCnda moqmedeba centralur nervul sistemaze.
dofaminis formulaa C6H3(OH)2-CH2-CH2-NH2.
dofamini kateqoloaminebis ojaxs miekuTvneba, sinTezirdeba
l-Tirozinisgan da warmoadgens adrenalinis da noradrenalinis prekursors.
dofaminis biosinTezi xdeba, rogorc centralur nervul sistemaSi, aseve Tirkmelzeda jirkvlis tvinovan nawilSi.
l- Tirozini gardaiqmneba, l-dopad, Semdeg dofaminad, dofaminis nawili adrenalin, noradrenalinad. dofamini „SeifuTeba“ patara buStukebSi da ise inaxeba neironebSi, saWiroebis SemTxvevaSi gamoTavisufldeba aqsonidan. dofaminis gamoTavisuflebis Semdeg xdeba misi ukumitaceba dofamin transporteris mier (DAT1) Semdeg xdeba misi daSla monoamin oqsidazas meSveobiT ((MAOA and MAOB) 3,4 dihidroqsifenilacetilis mJavad.
dofaminis funqciebia:
monawileobs SemecnebiT undarSi, swavlaSi;
monawileobs agreTve:
yuradReba;
maxsovroba;
enis gageba;
problemebis gadawyveta;
gadawyvetilebebis miReba;
nebiTi moZraobebi;
motivacia;
dasja da jildo;
prolaqtinis inhibireba (prolaqtini iwvevs laqtacia, seqsualur dakmayofilebas);
moqmedebs Zilze;
ganwyobaze;
samuSao maxsobrobaze.
Statiis saxeli : dofamini
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