dofamini

dofamini aris organuli nivTiereba kateqolaminebis ojaxidan, romelic mniSvnelovan rols TamaSobs adamianis organizmSi mimdinare fiziologiur procesebSi. dofamini Sedgeba aminis (NH2) jgufisgan, romelic dakavSirebulia kateqolis struqturasTan (dihidroqsifenilalanini- akronimiT DOPA).dofaminis saxelwodebac misi Semadgenlobidan momdinareobs.

adamianis organizmSi dofamini funqcionirebs, rogorc neirotransmiteri. cnobilia dofaminis xuTi saxis receptori: D1, D2, D3, D4, D5. dofamini gamomuSavdeba Tavis tvinis sxvadasxva adgilebSi mag. substancia nigra (ruxi nivTiereba) da ventral tegmentum (Sua tvinis zeviT mdebare birTvebi)

dofamini mniSvnelovan rols TamaSobs jildos sanacvlod swavlaSi, jildos miRebis dros oragnizmSi gamomuSavdeba dofamini, stimulantebi: kokaini, amfetaminebi moqmedeben dofaminis sistemaze da iwveven maTi raodenobis momatebas.

sxvadasxva kvlevis SedegebiT dadgenilia, rom eqstrovertebSi („jildos maZebari adamianebi“) ufro maRalia dofaminis koncentracia, vidre introvertebSi. cns (centraluri nervuli sistemis) ramodenime mniSvnelovani daavadeba asocirebulia dofaminis koncentraciis darRvevasTan: parkinsonis daavadeba, asakTan asocirebuli tremori da moZraobis darRvevebi (dakavSirebulia rux nivTierebaSi dofaminis sekretoruli neironebis raodenobis Semcireba), Sizofrenia – asocirebulia dofaminis momatebul raodenobasTan da aqtivobasTan prefrontalur qerqSi. yuradRebis deficitiT mimdinare hiperaqtiuri aSliloba- asocirebulia dofaminis dabal donesTan, Tavis tvinSi.

dofamini xelmisawvdomia intravenuri gamoyenebisTvis, axasiaTebs simpaTikuri aqtivoba (iwvevs dadebiT qronotropul moqmedebas, zrdis sisxlis wnevas, iwvevs dadebiT inotropul moqmedebas gulze da a.S.), Tumca intravenuri dofamini ver kveTs hemato-encefalur bariers, amitom ar aqvs centraluri nervuli sistemis mxriv simptomebi.

Tavis tvinze moqmedebs l-dopa (dofaminis prekursoria), romelic gamoiyeneba parkinsonis samkurnalod.

dofamini dasinTezirebul iqna pirvelad 1910 wels jorj bergeris